Antimicrobial ResistanceNDM1Round 3
NDM-1 Peptide Inhibitors
De novo peptide inhibitors targeting the NDM-1 di-zinc active site to restore meropenem efficacy against carbapenem-resistant gram-negative bacteria
NDM-1 (New Delhi Metallo-beta-lactamase 1) is a bacterial enzyme that destroys beta-lactam antibiotics — the most widely used class of antibiotics in the world. Bacteria carrying NDM-1 are resistant to nearly all available treatments, including last-resort carbapenems. A direct inhibitor of NDM-1 would restore the effectiveness of existing antibiotics against these otherwise untreatable infections.
9,670sequences generated
127promising drug leads
28verified jobs
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Docker command
# Requires NVIDIA GPU with 16 GB VRAM minimum docker run --gpus all ghcr.io/xenomine/miner:latest \ --api-key YOUR_API_KEY \ --jobs auto \ --program ndm1_peptide_v1
--gpus all — exposes all host GPUs to the container (required)--jobs auto — runs one job per GPU in parallel (default: 1)